LIBRA AbPro™-Recombinant Antibody Production Service
Recombinant Antibody Production Service
Based on the LIBRA™ antibody engineering platform, GeneMedi now provides antibody production services. In cooperation with the GM-LIBRA antibody expression group to achieve your antibody entities with high-throughout, high-quality, scalable, and state-of-the-Art Manufacturing.
Recombinant antibodies can be produced in various formats, including full-length, scFv, Fab, sdAb/VHH, Fc fusion protein, chimeric, and bispecific antibodies.
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About LIBRA™
LIBRA™ -Antibody Engineering Platform is GeneMedi’s innovative antibody engineering platform. LIBRA is developed with the characteristics such as Light, Intelligent, Balanced, Rational, and Algorithm-driven. LIBRA,(♎) is also Latin, meaning “Balance” in astrology.
About LIBRA HuEasy™
LIBRA HuEasy™ is a Machine learning-based antibody humanization technology to balance high affinity with low immunogenicity. LIBRA HuEasy™ is an easier, faster and highly accurate, which reduce the wet lab validation procedure.
About LIBRA AbPro™
LIBRA AbProTM is GeneMedi’s professional antibody production platform for various antibody and antibody-conjugate formats.
Definition: What is Recombinant Antibody Production?
Recombinant antibodies (rAbs) are monoclonal antibodies which are generated in vitro using antibody coding genes without immunizing any animals or cultivating any hybridomas. This technology involves recovering antibody genes from source cells, amplifying and cloning the genes into an appropriate phage vector, introducing the vector into a host (bacteria, yeast, or mammalian cell lines), and achieving expression of adequate amounts of functional antibody. Recombinant antibodies maintain high standard of specificity and low immunogenicity. Recombinant antibodies are becoming indispensable tools for basic research, diagnostics, and clinical applications.
Recombinant antibodies can be produced in various formats: full-length, scFv, Fab, sdAb/VHH, Fc fusion protein, chimeric, and bispecific antibodies
Every full-length immunoglobulin (IgG) molecule consists of two light and heavy chains connected by disulfide bonds. Recombinant antibodies can come in different formats, including: full-length immunoglobulins (Ig), monovalent antibody fragments such as single-chain fragment variable (scFv) and fragment antigen-binding (Fab), and multimeric formats such as diabodies (dimeric scFvs) or triabodies (trimeric scFvs). Antibody fragments, like scFv, Fab and VHH, are small in size, thereby offering improved penetration of tissues or tumors compared to their full-length counterparts.
Do I need to renew my license?
How to produce Recombinant Antibody?--Expression platform & Procedure & Protocol
Case study: Data of Antibody Production
1. SDS-PAGE
The result of SDS-PAGE under reducing conditions shows that the purity of the antibody is >95%.
2. SEC-HPLC
The result of SEC-HPLC shows that the purity of the antibody is >90%.
3. ELISA
GeneMedi’s SARS-CoV-2 NP Antibody Pairs Validation In Sandwich ELISA.
